Background and aims: Familial hypercholesterolemia FH is among the most common genetic disorders in primary care. Methods: We evaluated consolidated datasets from FH patients diagnosed clinically and seen either by lipid specialists or general practitioners and internists. We conducted a questionnaire survey of both the recruiting physicians and patients. High intensity lipid-lowering was administered more often in men than in women, in patients with ASCVD, at higher LDL-C and in patients with a genetic diagnosis of FH. Conclusions: FH is under-treated in Germany compared to guideline recommendations. Male gender, genetic proof of FH, treatment by a specialist, and presence of ASCVD appear to be associated with increased treatment intensity. Keywords: Adherence; Cardiovascular risk; Cascade screening; Familial hypercholesterolemia; Low-density lipoproteins; Patient registry; Treatment. Abstract Background and aims: Familial hypercholesterolemia FH is among the most common genetic disorders in primary care. Publication types Review.
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